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Pavan Kumar, K.
- Substantial Purification of Waste Glycerol – A Byproduct of Biofuel Industry its Product Characterization
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Authors
Affiliations
1 Department of Biotechnology, Vivekanandha College of Engineering for Women, Elayampalayam, Tiruchengode, Namakkal, IN
1 Department of Biotechnology, Vivekanandha College of Engineering for Women, Elayampalayam, Tiruchengode, Namakkal, IN
Source
Research Journal of Pharmacy and Technology, Vol 12, No 2 (2019), Pagination: 649-654Abstract
An increase in greenhouse gas effect and depletion of fossil fuel leads to work on alternate renewable source of energy. Biofuel, in which biodiesel has gained its importance over a decade due to its promising characteristics. Crude glycerol is produced as an inevitable byproduct during biodiesel production. The carbon content of the waste glycerol can be utilized by many microorganisms as a cheap carbon and energy source for the production of high value chemicals like ethanol, citric acid, propanediol etc. In this present work simple sequential procedures like distillation, acidification, activated charcoal adsorption, filtration and centrifugation were carried out made to remove major impurities economically and increases the glycerol concentration. The removal of impurities from crude glycerol and the increase in the concentration of glycerol were witnessed from GCMS and GC-FID reports. The procedure followed in this work provided a realistic and concrete target shows a momentous proliferation of increased glycerol concentration from 10.43% to 44 %. The other properties of glycerol were studied and compared with standard methods.Keywords
Biodiesel, Crude Glycerol, High-Value Chemicals, GC-MS and GC-FID.
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- Rapid Quantitative Estimation of Glipizide and Sitagliptin in Rat Plasma by Liquid Chromatography and Mass Spectroscopy (Lc-ms)
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Authors
A. Anka Rao
1,
K. Pavan Kumar
2,
A. Narayana Rao
1,
Narender Malothu
1,
B. Prassana Kumar Desu
1,
Naga Raju Bandaru
1
Affiliations
1 K L College of Pharmacy, Koneru Lakshmaiah Education Foundation, Vaddeswaram, Andhra Pradesh - 522 502., IN
2 Research Scholar, K L College of Pharmacy, Koneru Lakshmaiah Education Foundation, Vaddeswaram, Andhra Pradesh-522 502., IN
1 K L College of Pharmacy, Koneru Lakshmaiah Education Foundation, Vaddeswaram, Andhra Pradesh - 522 502., IN
2 Research Scholar, K L College of Pharmacy, Koneru Lakshmaiah Education Foundation, Vaddeswaram, Andhra Pradesh-522 502., IN
Source
Research Journal of Pharmacy and Technology, Vol 15, No 4 (2022), Pagination: 1675-1679Abstract
Objective: Highly responsive simple Liquid-liquid Extraction Glipizide development using deuterated Glipizide and Sitagliptin LC-MS/MS Glipizide for gradation of Glipizide and Sitagliptin in rat plasma Glipizide: The chromatographic condition involves, isocratic mode using waters X-Bridge C18 3.5μ (150x4.6mm) column. Mobile phase 0.1% orthophosphoric acid and Acetonitrile in the ratio (80:20) was used and detection was carried out in a positive mode of electrospray ionization by using MS. Results: Glipizide has been validated, the linearity was observed in the range 10-150 ng/ml and 0.1-1.5 ng/ml for Glipizide and Sitagliptin respectively. For intraday and inter-day precision %RSD values were found to be within the acceptable limits. Recovery studies for Glipizide and Sitagliptin obtained was 99.5% and 98.6% respectively. The battery of stability studies like bench-top, Autosampler stability, freeze-thaw, and long term stability was performed. Conclusion: Highly responsive simple liquid chromatography tandem mass spectroscopy assay Glipizidewas developed and witnessed for the gradation of Glipizideand Sitagliptin in rat plasma, the developed Glipizidewas applied to pharmacokinetic studies.Keywords
LCMS, Glipizide, Sitagliptin, Glipizidevalidation, pharmacokinetic study.References
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